The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation

Stably integrated transgenes flanked by the chicken β-globin HS4 insulator are protected against chromosomal position effects and gradual extinction of expression during long-term propagation in culture. To investigate the mechanism of action of this insulator, we used bisulfite genomic sequencing t...

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Bibliographic Details

Published in:	Genes Dev
Main Authors:	Mutskov, Vesco J., Farrell, Catherine M., Wade, Paul A., Wolffe, Alan P., Felsenfeld, Gary
Format:	Artigo
Language:	Inglês
Published:	Cold Spring Harbor Laboratory Press 2002
Subjects:	Research Paper
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186352/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12080092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.988502
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