Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities

The 1.2-kb DNA sequence element (5′HS4) at the 5′ end of the chicken β-globin locus has the two defining properties of an insulator: it prevents an “external” enhancer from acting on a promoter when placed between them (“enhancer blocking”) and acts as a barrier to chromosomal position effect (CPE)...

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Main Authors: Recillas-Targa, Félix, Pikaart, Michael J., Burgess-Beusse, Bonnie, Bell, Adam C., Litt, Michael D., West, Adam G., Gaszner, Miklos, Felsenfeld, Gary
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC124498/
https://ncbi.nlm.nih.gov/pubmed/12011446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102179399
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