Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
The constitutive DNase I hypersensitive site at the 5′ end of the chicken β-globin locus marks the boundary of the active chromatin domain in erythroid cells. The DNA sequence containing this site has the properties of an insulator, as shown by its ability in stable transformation experiments to blo...
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| Publicado no: | Genes Dev |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317165/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9744862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.18.2852 |
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