Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
The constitutive DNase I hypersensitive site at the 5′ end of the chicken β-globin locus marks the boundary of the active chromatin domain in erythroid cells. The DNA sequence containing this site has the properties of an insulator, as shown by its ability in stable transformation experiments to blo...
সংরক্ষণ করুন:
| প্রকাশিত: | Genes Dev |
|---|---|
| প্রধান লেখক: | , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
Cold Spring Harbor Laboratory Press
1998
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317165/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9744862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.18.2852 |
| ট্যাগগুলো: |
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