Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

The constitutive DNase I hypersensitive site at the 5′ end of the chicken β-globin locus marks the boundary of the active chromatin domain in erythroid cells. The DNA sequence containing this site has the properties of an insulator, as shown by its ability in stable transformation experiments to blo...

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Detalles Bibliográficos

Publicado en:	Genes Dev
Autores principales:	Pikaart, Michael J., Recillas-Targa, Félix, Felsenfeld, Gary
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 1998
Materias:	Research Paper
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317165/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9744862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.18.2852
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