The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation

The kinase activity of Abl is known to be regulated by a putative trans-acting inhibitor molecule interacting with the Src homology (SH) 3 domain of Abl. Here we report that the kinase-deficient Src (SrcKD) directly inhibits the tyrosine phosphorylation of Cbl and other cellular proteins by Abl. We...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Shishido, Tomoyuki, Akagi, Tsuyoshi, Ouchi, Toru, Georgescu, Maria-Magdalena, Langdon, Wallace Y., Hanafusa, Hidesaburo
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829062/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.060030697
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