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The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation

The kinase activity of Abl is known to be regulated by a putative trans-acting inhibitor molecule interacting with the Src homology (SH) 3 domain of Abl. Here we report that the kinase-deficient Src (SrcKD) directly inhibits the tyrosine phosphorylation of Cbl and other cellular proteins by Abl. We...

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Bibliografiske detaljer
Main Authors: Shishido, Tomoyuki, Akagi, Tsuyoshi, Ouchi, Toru, Georgescu, Maria-Magdalena, Langdon, Wallace Y., Hanafusa, Hidesaburo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18621/
https://ncbi.nlm.nih.gov/pubmed/10829062
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