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A mechanistic basis for Mre11-directed DNA joining at microhomologies

Repair of DNA double-strand breaks in vertebrate cells occurs mainly by an end-joining process that often generates junctions with sequence homologies of a few nucleotides. Mre11 is critical for this mode of repair in budding yeast and has been implicated in the microhomology-based joining. Here, we...

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Detalhes bibliográficos
Main Authors: Paull, Tanya T., Gellert, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18616/
https://ncbi.nlm.nih.gov/pubmed/10823903
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