Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer

Sphingolipid metabolites such as sphingosine-1-phosphate (S1P) and ceramide modulate apoptosis during development and in response to stress. In general, ceramide promotes apoptosis, whereas S1P stimulates cell proliferation and protects against apoptosis. S1P is irreversibly degraded by the enzyme S...

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Autori principali: Oskouian, Babak, Sooriyakumaran, Prathap, Borowsky, Alexander D., Crans, Angelina, Dillard-Telm, Lisa, Tam, Yuen Yee, Bandhuvula, Padmavathi, Saba, Julie D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859938/
https://ncbi.nlm.nih.gov/pubmed/17090686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600050103
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