The same genomic region conditions clonal deletion and clonal deviation to the CD8αα and regulatory T cell lineages in NOD versus C57BL/6 mice

Clonal deviation is a mechanism by which immature thymocytes expressing a self-reactive T cell antigen receptor (TCR) are rescued from clonal deletion by adopting an alternative differentiation pathway resistant to apoptosis. Here, we confirm and generalize previous indications that genetic alleles...

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Detaylı Bibliyografya
Asıl Yazarlar: Holler, Phillip D., Yamagata, Tetsuya, Jiang, Wenyu, Feuerer, Markus, Benoist, Christophe, Mathis, Diane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855402/
https://ncbi.nlm.nih.gov/pubmed/17438291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701777104
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