Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer

PURPOSE: To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in patients with advanced cancer. PATIENTS AND METHODS: Patients with solid and hematologic malignancies were t...

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Detalhes bibliográficos
Main Authors: Kelly, William Kevin, O’Connor, Owen A., Lee Krug, M., Chiao, Judy H., Heaney, Mark, Curley, Tracy, MacGregore-Cortelli, Barbara, Tong, William, Secrist, J. Paul, Schwartz, Lawrence, Richardson, Stacy, Chu, Elaina, Olgac, Semra, Marks, Paul A., Scher, Howard, Richon, Victoria M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855284/
https://ncbi.nlm.nih.gov/pubmed/15897550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2005.14.167
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