CDKN2A Gene Deletions and Loss of p16 Expression Occur in Osteosarcomas That Lack RB Alterations

Osteosarcomas often suffer mutations of the RB (retinoblastoma) gene, with resultant inactivation of the pRb protein. pRb is one component in a cell-cycle control pathway that includes the p16 (encoded by the CDKN2A gene) and cyclin-dependent kinase 4 (cdk4, encoded by the CDK4 gene) proteins. We th...

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Hauptverfasser: Nielsen, Gunnlaugur P., Burns, Karen L., Rosenberg, Andrew E., Louis, David N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 1998
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852953/
https://ncbi.nlm.nih.gov/pubmed/9665476
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