CDKN2A Gene Deletions and Loss of p16 Expression Occur in Osteosarcomas That Lack RB Alterations

Osteosarcomas often suffer mutations of the RB (retinoblastoma) gene, with resultant inactivation of the pRb protein. pRb is one component in a cell-cycle control pathway that includes the p16 (encoded by the CDKN2A gene) and cyclin-dependent kinase 4 (cdk4, encoded by the CDK4 gene) proteins. We th...

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Hlavní autoři: Nielsen, Gunnlaugur P., Burns, Karen L., Rosenberg, Andrew E., Louis, David N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 1998
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852953/
https://ncbi.nlm.nih.gov/pubmed/9665476
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