Loss of heterozygosity of CDKN2A (p16INK4a) and RB1 tumor suppressor genes in testicular germ cell tumors

BACKGROUND: Testicular germ cell tumors (TGCTs) are the most frequent malignances in young adult men. The two main histological forms, seminomas and nonseminomas, differ biologically and clinically. pRB protein and its immediate upstream regulator p16INK4a are involved in the RB pathway which is der...

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Bibliographic Details
Main Authors: Vladusic, Tomislav, Hrascan, Reno, Pecina-Slaus, Nives, Vrhovac, Ivana, Gamulin, Marija, Franekic, Jasna, Kruslin, Bozo
Format: Artigo
Language:Inglês
Published: Versita, Warsaw 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423692/
https://ncbi.nlm.nih.gov/pubmed/22933911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/v10019-010-0035-7
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