Channel Opening by Anesthetics and GABA Induces Similar Changes in the GABA(A) Receptor M2 Segment

For many general anesthetics, their molecular basis of action involves interactions with GABA(A) receptors. Anesthetics produce concentration-dependent effects on GABA(A) receptors. Low concentrations potentiate submaximal GABA-induced currents. Higher concentrations directly activate the receptors....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rosen, Ayelet, Bali, Moez, Horenstein, Jeffrey, Akabas, Myles H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Biophysical Society 2007
Pynciau:
Channels, Receptors, and Electrical Signaling
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852347/
https://ncbi.nlm.nih.gov/pubmed/17293408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.094490
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