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Facilitating matched pairing and expression of TCR chains introduced into human T cells

Adoptive transfer of T lymphocytes is a promising treatment for a variety of malignancies but often not feasible due to difficulties generating T cells that are reactive with the targeted antigen from patients. To facilitate rapid generation of cells for therapy, T cells can be programmed with genes...

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Главные авторы: Kuball, Jürgen, Dossett, Michelle L., Wolfl, Matthias, Ho, William Y., Voss, Ralf-Holger, Fowler, Carla, Greenberg, Philip D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852191/
https://ncbi.nlm.nih.gov/pubmed/17082316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-023069
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