A Potent Tumor-Reactive p53-Specific Single-Chain TCR without On- or Off-Target Autoimmunity In Vivo

Genetic engineering of T cells with a T cell receptor (TCR) targeting tumor antigen is a promising strategy for cancer immunotherapy. Inefficient expression of the introduced TCR due to TCR mispairing may limit the efficacy and adversely affect the safety of TCR gene therapy. Here, we evaluated the...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Echchannaoui, Hakim, Petschenka, Jutta, Ferreira, Edite Antunes, Hauptrock, Beate, Lotz-Jenne, Carina, Voss, Ralf-Holger, Theobald, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319330/
https://ncbi.nlm.nih.gov/pubmed/30528087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.11.006
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