Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity

BACKGROUND: Tumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53 isoforms in cellular senescence process of non-immune cells. However, their...

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Detalles Bibliográficos
Publicado en:J Immunother Cancer
Main Authors: Legscha, Kevin Jan, Antunes Ferreira, Edite, Chamoun, Antonios, Lang, Alexander, Awwad, Mohamed Hemaid Sayed, Ton, Gigi Nu Hoang Quy, Galetzka, Danuta, Guezguez, Borhane, Hundemer, Michael, Bourdon, Jean-Christophe, Munder, Markus, Theobald, Matthias, Echchannaoui, Hakim
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2021
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8194333/
https://ncbi.nlm.nih.gov/pubmed/34112738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001846
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