Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells

BACKGROUND: Genetically engineered virus-specific T cells (VSTs) are a platform for adoptive cell therapy after allogeneic hematopoietic stem cell transplantation. However, redirection to a tumor-associated antigen by the introduction of a transgenic T-cell receptor (TCR) reduces anti-viral activity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunother Cancer
Prif Awduron: Bajwa, Gagan, Lanz, Inès, Cardenas, Mara, Brenner, Malcolm K, Arber, Caroline
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Publishing Group 2020
Pynciau:
Immune Cell Therapies and Immune Cell Engineering
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7640589/
https://ncbi.nlm.nih.gov/pubmed/33148692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001487
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