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Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli

A sequence-specific ribozyme (M1GS RNA) derived from the catalytic RNA subunit of RNase P from Escherichia coli was used to target the overlapping exon 3 region of the mRNAs encoding the major transcription regulatory proteins IE1 and IE2 of human cytomegalovirus. A reduction of more than 80% in the...

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書誌詳細
主要な著者: Trang, Phong, Lee, Manfred, Nepomuceno, Edward, Kim, Joe, Zhu, Hua, Liu, Fenyong
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC18516/
https://ncbi.nlm.nih.gov/pubmed/10811889
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