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Inhibition of CFTR Cl(−) channel function caused by enzymatic hydrolysis of sphingomyelin
Numerous mutations in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR, a Cl(−) channel) disrupt salt and fluid transport and lead to the formation of thick mucus in patients' airways. Obstruction by mucus predisposes CF patients to chronic infections and inflammation, which b...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851081/ https://ncbi.nlm.nih.gov/pubmed/17400751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701354104 |
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