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Glucose Stimulation of Transforming Growth Factor-β Bioactivity in Mesangial Cells Is Mediated by Thrombospondin-1

Glucose is a key factor in the development of diabetic complications, including diabetic nephropathy. The development of diabetic glomerulosclerosis is dependent on the fibrogenic growth factor, transforming growth factor-β (TGF-β). Previously we showed that thrombospondin-1 (TSP-1) activates latent...

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Hlavní autoři: Poczatek, Maria H., Hugo, Christian, Darley-Usmar, Victor, Murphy-Ullrich, Joanne E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850177/
https://ncbi.nlm.nih.gov/pubmed/11021838
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