A Thrombospondin-1 Antagonist of Transforming Growth Factor-β Activation Blocks Cardiomyopathy in Rats with Diabetes and Elevated Angiotensin II

In diabetes and hypertension, the induction of increased transforming growth factor-β (TGF-β) activity due to glucose and angiotensin II is a significant factor in the development of fibrosis and organ failure. We showed previously that glucose and angiotensin II induce the latent TGF-β activator th...

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Hlavní autoři: Belmadani, Souad, Bernal, Juan, Wei, Chih-Chang, Pallero, Manuel A., Dell’Italia, Louis, Murphy-Ullrich, Joanne E., Berecek, Kathleen H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2007
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1959499/
https://ncbi.nlm.nih.gov/pubmed/17640965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070056
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