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A Thrombospondin-1 Antagonist of Transforming Growth Factor-β Activation Blocks Cardiomyopathy in Rats with Diabetes and Elevated Angiotensin II
In diabetes and hypertension, the induction of increased transforming growth factor-β (TGF-β) activity due to glucose and angiotensin II is a significant factor in the development of fibrosis and organ failure. We showed previously that glucose and angiotensin II induce the latent TGF-β activator th...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1959499/ https://ncbi.nlm.nih.gov/pubmed/17640965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070056 |
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