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Critical Role of the N-Loop and β1-Strand Hydrophobic Clusters of RANTES-Derived Peptides in Anti-HIV Activity
HIV initiates its infectious cycle by docking to CD4 and a chemokine receptor, most commonly CCR5. RANTES, a natural CCR5 ligand, is a potent inhibitor of HIV-1. Despite the lack of structural information on the RANTES-CCR5 complex, determinants of HIV blockade were previously identified within the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850098/ https://ncbi.nlm.nih.gov/pubmed/17083916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.10.090 |
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