Cryptic Nature of a Conserved, CD4-Inducible V3 Loop Neutralization Epitope in the Native Envelope Glycoprotein Oligomer of CCR5-Restricted, but Not CXCR4-Using, Primary Human Immunodeficiency Virus Type 1 Strains

The external subunit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env), gp120, contains conserved regions that mediate sequential interactions with two cellular receptor molecules, CD4 and a chemokine receptor, most commonly CCR5 or CXCR4. However, antibody accessibility...

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Detalhes bibliográficos
Main Authors: Lusso, Paolo, Earl, Patricia L., Sironi, Francesca, Santoro, Fabio, Ripamonti, Chiara, Scarlatti, Gabriella, Longhi, Renato, Berger, Edward A., Burastero, Samuele E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112133/
https://ncbi.nlm.nih.gov/pubmed/15890935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.6957-6968.2005
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