Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity

The chemokine receptor CCR5 is utilized as a critical coreceptor by most primary HIV-1 strains. While the lack of structural information on CCR5 has hampered the rational design of specific inhibitors, mimetics of the chemokines that naturally bind CCR5 can be molecularly engineered. We used a struc...

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Detalhes bibliográficos
Main Authors: Lusso, Paolo, Vangelista, Luca, Cimbro, Raffaello, Secchi, Massimiliano, Sironi, Francesca, Longhi, Renato, Faiella, Marina, Maglio, Ornella, Pavone, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058712/
https://ncbi.nlm.nih.gov/pubmed/21199933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-167627
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