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Rational CCL5 mutagenesis integration in a lactobacilli platform generates extremely potent HIV-1 blockers
Efforts to improve existing anti-HIV-1 therapies or develop preventatives have identified CCR5 as an important target and CCL5 as an ideal scaffold to sculpt potent HIV-1 entry inhibitors. We created novel human CCL5 variants that exhibit exceptional anti-HIV-1 features using recombinant lactobacill...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5790001/ https://ncbi.nlm.nih.gov/pubmed/29382912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20300-9 |
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