NBK/BIK antagonizes MCL-1 and BCL-X(L) and activates BAK-mediated apoptosis in response to protein synthesis inhibition

Ribonucleases, antibiotics, bacterial toxins, and viruses inhibit protein synthesis, which results in apoptosis in mammalian cells. How the BCL-2 family of proteins regulates apoptosis in response to the shutoff of protein synthesis is not known. Here we demonstrate that an Escherichia coli toxin, M...

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Autors principals: Shimazu, Tsutomu, Degenhardt, Kurt, Nur-E-Kamal, Alam, Zhang, Junjie, Yoshida, Takeshi, Zhang, Yonglong, Mathew, Robin, White, Eileen, Inouye, Masayori
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2007
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847711/
https://ncbi.nlm.nih.gov/pubmed/17403773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1522007
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