AT-rich repeats associated with chromosome 22q11.2 rearrangement disorders shape human genome architecture on Yq12

Low copy repeats (LCRs; segmental duplications) constitute ∼5% of the sequenced human genome. Nonallelic homologous recombination events between LCRs during meiosis can lead to chromosomal rearrangements responsible for many genomic disorders. The 22q11.2 region is susceptible to recurrent and nonre...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Babcock, Melanie, Yatsenko, Svetlana, Stankiewicz, Pawel, Lupski, James R., Morrow, Bernice E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2007
Ämnen:
Letter
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1832092/
https://ncbi.nlm.nih.gov/pubmed/17284672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.5651507
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