A fourth IκB protein within the NF-κB signaling module

Inflammatory NF-κB/RelA activation is mediated by the three canonical inhibitors, IκBα, -β, and -ε. We report here that nfκb2/p100 forms two distinct inhibitory complexes with RelA, one of which mediates developmental NF-κB activation. Our genetic evidence confirms that p100 is required and sufficie...

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Main Authors: Basak, Soumen, Kim, Hana, Kearns, Jeffrey D., Tergaonkar, Vinay, O’Dea, Ellen, Werner, Shannon L., Benedict, Chris A., Ware, Carl F., Ghosh, Gourisankar, Verma, Inder M., Hoffmann, Alexander
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1831796/
https://ncbi.nlm.nih.gov/pubmed/17254973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.12.033
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