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Mechanisms of Copper Ion Mediated Huntington's Disease Progression
Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are increased in the striata of HD patients, but the role of these metals in...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1828629/ https://ncbi.nlm.nih.gov/pubmed/17396163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000334 |
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