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Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

The ataxia-telangiectasia mutated (ATM) 1 and ATM- and Rad3-related (ATR) protein kinases are crucial regulatory proteins in genotoxic stress response pathways that pause the cell cycle to permit DNA repair. Here we show that Chk1 phosphorylation in response to hydroxyurea (HU) and ultraviolet radia...

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Detalles Bibliográficos
Main Authors: Myers, Jeremy S., Cortez, David
Formato: Artigo
Idioma:Inglês
Publicado: 2006
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821075/
https://ncbi.nlm.nih.gov/pubmed/16431910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M513265200
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