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Liver repopulation with xenogenic hepatocytes in B and T cell- deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma
To investigate host and viral mechanisms determining hepadnaviral persistence and hepatocarcinogenesis, we developed a mouse model by transplanting woodchuck hepatocytes into the liver of mice that contain the urokinase-type plasminogen activator transgene (uPA) and lack mature B and T lymphocytes d...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1998
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC18210/ https://ncbi.nlm.nih.gov/pubmed/9419372 |
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