Liver repopulation with xenogenic hepatocytes in B and T cell- deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma

To investigate host and viral mechanisms determining hepadnaviral persistence and hepatocarcinogenesis, we developed a mouse model by transplanting woodchuck hepatocytes into the liver of mice that contain the urokinase-type plasminogen activator transgene (uPA) and lack mature B and T lymphocytes d...

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Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Petersen, Joerg, Dandri, Maura, Gupta, Sanjeev, Rogler, Charles E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9419372/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.1.310
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