Liver repopulation with xenogenic hepatocytes in B and T cell- deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma
To investigate host and viral mechanisms determining hepadnaviral persistence and hepatocarcinogenesis, we developed a mouse model by transplanting woodchuck hepatocytes into the liver of mice that contain the urokinase-type plasminogen activator transgene (uPA) and lack mature B and T lymphocytes d...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9419372/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.1.310 |
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