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TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements

In mammalian cells, mRNAs with AU-rich elements (AREs) are targeted for translational silencing and rapid degradation. Here we present evidence that in human cells the proteins Tristetraprolin (TTP) and BRF-1 deliver ARE-mRNAs to processing bodies (PBs), cytoplasmic assemblies of mRNAs, and associat...

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Bibliografiske detaljer
Main Authors: Franks, Tobias M., Lykke-Andersen, Jens
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820945/
https://ncbi.nlm.nih.gov/pubmed/17369404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1494707
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