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TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements
In mammalian cells, mRNAs with AU-rich elements (AREs) are targeted for translational silencing and rapid degradation. Here we present evidence that in human cells the proteins Tristetraprolin (TTP) and BRF-1 deliver ARE-mRNAs to processing bodies (PBs), cytoplasmic assemblies of mRNAs, and associat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820945/ https://ncbi.nlm.nih.gov/pubmed/17369404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1494707 |
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