Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

The zinc finger protein tristetraprolin (TTP) promotes translation repression and degradation of mRNAs containing AU-rich elements (AREs). Although much attention has been directed toward understanding the decay process and machinery involved, the translation repression role of TTP has remained poor...

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Published in:RNA
Main Authors: Fu, Rui, Olsen, Myanna T., Webb, Kristofor, Bennett, Eric J., Lykke-Andersen, Jens
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748815/
https://ncbi.nlm.nih.gov/pubmed/26763119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.054833.115
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