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Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

In human cells, a critical pathway in gene regulation subjects mRNAs with AU-rich elements (AREs) to rapid decay by a poorly understood process. AREs have been shown to directly activate deadenylation, decapping, or 3′-to-5′ exonucleolytic decay. We demonstrate that enzymes involved in all three of...

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Bibliografiske detaljer
Main Authors: Lykke-Andersen, Jens, Wagner, Eileen
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC546513/
https://ncbi.nlm.nih.gov/pubmed/15687258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1282305
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