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Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1
In human cells, a critical pathway in gene regulation subjects mRNAs with AU-rich elements (AREs) to rapid decay by a poorly understood process. AREs have been shown to directly activate deadenylation, decapping, or 3′-to-5′ exonucleolytic decay. We demonstrate that enzymes involved in all three of...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC546513/ https://ncbi.nlm.nih.gov/pubmed/15687258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1282305 |
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