The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

The p16(INK4A) and p14(ARF) proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood. Here, we show that the ability of the oncogene BMI1 to repress the INK4A-ARF locus requires its direct associati...

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Detalhes bibliográficos
Main Authors: Bracken, Adrian P., Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, Theilgaard-Mönch, Kim, Minucci, Saverio, Porse, Bo T., Marine, Jean-Christophe, Hansen, Klaus H., Helin, Kristian
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820894/
https://ncbi.nlm.nih.gov/pubmed/17344414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.415507
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