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Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts – role of myofilament Ca(2+) sensitivity increase
Troponin T (TnT) mutations that cause familial hypertrophic cardiomyopathy (FHC) and sudden cardiac death frequently increase myofilament Ca(2+) sensitivity, suggesting that their Ca(2+)-sensitizing effect contributes importantly to the FHC pathogenesis. To test this hypothesis, we compared transgen...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2006
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1819413/ https://ncbi.nlm.nih.gov/pubmed/16777946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.107557 |
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