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Antiviral and immunoregulatory activities of IFN-γ depend on constitutively expressed IL-1α

IFN-γ induces its immunoregulatory activities by activating genes mainly through the Jak-STAT signaling pathway. Here we show that what was considered to be intrinsic IFN-γ activities depend largely on the basal level of NF-κB, which is maintained by constitutively expressed IL-1α. The IL-1 receptor...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Hurgin, Vladimir, Novick, Daniela, Werman, Ariel, Dinarello, Charles A., Rubinstein, Menachem
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817830/
https://ncbi.nlm.nih.gov/pubmed/17360358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611608104
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