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IL-12–induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor

IL-12 and IL-18 are IFN-γ–inducing cytokines. In the present study, the role of endogenous IL-18 in the induction of IFN-γ by IL-12 was investigated in mice. In the presence of a specific inhibitor of caspase-1 (also known as IL-1β–converting enzyme, or ICE) IL-12–induced IFN-γ from splenocytes was...

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Bibliografische gegevens
Hoofdauteurs: Fantuzzi, Giamila, Reed, David A., Dinarello, Charles A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC408443/
https://ncbi.nlm.nih.gov/pubmed/10491411
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