Impaired IL-18 processing protects caspase-1–deficient mice from ischemic acute renal failure

We sought to determine whether mice deficient in the proinflammatory caspase-1, which cleaves precursors of IL-1β and IL-18, were protected against ischemic acute renal failure (ARF). Caspase-1(–/–) mice developed less ischemic ARF as judged by renal function and renal histology. These animals had s...

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Hauptverfasser: Melnikov, Vyacheslav Y., Ecder, Tevfik, Fantuzzi, Giamila, Siegmund, Britta, Lucia, M. Scott, Dinarello, Charles A., Schrier, Robert W., Edelstein, Charles L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209282/
https://ncbi.nlm.nih.gov/pubmed/11342578
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