Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL-18 and thereby suppresses the production of IFN-γ, resulting in reduced T-helper type 1 immune responses. In the present study, four human and two mouse isoforms, resulting from mRNA splicing and found in v...

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Главные авторы: Kim, Soo-Hyun, Eisenstein, Miriam, Reznikov, Leonid, Fantuzzi, Giamila, Novick, Daniela, Rubinstein, Menachem, Dinarello, Charles A.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2000
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC15564/
https://ncbi.nlm.nih.gov/pubmed/10655506
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