Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL-18 and thereby suppresses the production of IFN-γ, resulting in reduced T-helper type 1 immune responses. In the present study, four human and two mouse isoforms, resulting from mRNA splicing and found in v...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Kim, Soo-Hyun, Eisenstein, Miriam, Reznikov, Leonid, Fantuzzi, Giamila, Novick, Daniela, Rubinstein, Menachem, Dinarello, Charles A.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2000
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15564/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10655506/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.3.1190
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