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Antiviral and immunoregulatory activities of IFN-γ depend on constitutively expressed IL-1α
IFN-γ induces its immunoregulatory activities by activating genes mainly through the Jak-STAT signaling pathway. Here we show that what was considered to be intrinsic IFN-γ activities depend largely on the basal level of NF-κB, which is maintained by constitutively expressed IL-1α. The IL-1 receptor...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1817830/ https://ncbi.nlm.nih.gov/pubmed/17360358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611608104 |
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