Impaired angiogenesis in aminopeptidase N-null mice

Aminopeptidase N (APN, CD13; EC 3.4.11.2) is a transmembrane metalloprotease with several functions, depending on the cell type and tissue environment. In tumor vasculature, APN is overexpressed in the endothelium and promotes angiogenesis. However, there have been no reports of in vivo inactivation...

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Autores principales: Rangel, Roberto, Sun, Yan, Guzman-Rojas, Liliana, Ozawa, Michael G., Sun, Jessica, Giordano, Ricardo J., Van Pelt, Carolyn S., Tinkey, Peggy T., Behringer, Richard R., Sidman, Richard L., Arap, Wadih, Pasqualini, Renata
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815469/
https://ncbi.nlm.nih.gov/pubmed/17360568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611653104
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